MOTS-c

MOTS-c is a mitochondrial-derived peptide that has gained interest in metabolic and aging research for its role in regulating energy balance, insulin sensitivity, and cellular stress responses. It is encoded within mitochondrial DNA and is thought to act as a signaling molecule that helps cells adapt to metabolic stress.

In preclinical studies, MOTS-c has been investigated for its potential effects on glucose metabolism, fat oxidation, and exercise endurance by influencing key pathways involved in energy production and homeostasis, including AMPK activation. Researchers also explore its possible role in age-related metabolic decline and mitochondrial function. While promising in experimental models, it is still considered a research compound and is not approved as a therapeutic medication for general clinical use.